Description

Codes indicating diagnosis of asplenia or dysplenia (acquired or congenital)

Methodology

This codelist was derived by the following method:

• Read 2 Codelist provided by LSHTM. See references for paper.
• Codes from Quality Outcome Framework (QOF) were examined and relevant spleen codes taken
• Codes from SNOMED were taken by searching for relevant spleen terms

These 3 lists were mapped into CTV3 by TPP to create one list. This list was examined by 2 people and the following logic applied (see github issue for more detail):

• Splenomegaly or splenic cysts excluded as no evidence of reduced function
• Congenital syphilis which appears in the list due to one code with congenital syphilitic splenomegaly was excluded. Congenital syphilitic splenomegaly was included however.
• All unspecified injuries to spleen for example trauma were excluded except where removal of spleen was specified.
• Removal of accessory spleen was excluded

References

• Discussion on GitHub issue
• Grint DJ, McDonald HI, Walker JL, Amirthalingam G, Andrews N, Thomas S. Safety of inadvertent administration of live zoster vaccine to immunosuppressed individuals in a UK-based observational cohort analysis. BMJ Open. 2020;10(1):e034886.

Signed off by

• Caroline Morton, (April 14, 2020)
• Alex Walker, (April 14, 2020)
• Henry Drysdale, (June 2, 2020)